Attention architects. Is it possible?  

I'm digging for my copy of...
I'm digging for my copy of Metropolis, which has an interesting feature about pre-fab. (June, o8, p70-73)
Ha! Found it! Brett Zamore is designing modular homes based on shot-gun cottages starting at $100/sf. According to the feature PreFab suffers from shipping costs, as the modules are produced in one location and shipped to the site.
"By contrast, Zamore homes, which aren't prefabs, use components that are ordered locally and assembled on site." Zamore also saves money by building the homes based around standard sized lumber - which cuts contractors costs as they can focus less on measuring and cutting, and also less waste.
http://www.zamorehomes.com

SC-more doublewides per capita than anywhere else
I live in the land of doublewides and they transport them on flatbeds in two long pieces with the open side covered with Tyvek. They have to pay two pickup truck drivers to drive in front of and behind the flatbed with "Wide Load" signs and flashing lights.
Obviously, transportation costs for trailers is not very high because, hey, it's a mobile home and the buyer would typically not be able to afford high installation costs.
No one has answered Whitespike's original question. Are there no architects who read this forum?

Not trailers but
In referencing WS's original post there is a gal who is doing something very similar to your trailer idea (courtyards etc) but doing it with shipping containers to house workes in a Mexican factory city. When I get home I'll try to see if I can find the link.

A fun read:
A fun read:
http://www.trailerwrap.net/